ParkinsonCanadaV1, Main, Exploration, bibRecord, 005642

Evaluation of the integrity of the dopamine system in a rodent model of Parkinson's disease: small animal positron emission tomography compared to behavioral assessment and autoradiography.

Identifieur interne : 005642 ( Main/Exploration ); précédent : 005641; suivant : 005643

Evaluation of the integrity of the dopamine system in a rodent model of Parkinson's disease: small animal positron emission tomography compared to behavioral assessment and autoradiography.

Auteurs : Elissa M. Strome [Canada] ; Ivan L. Cepeda ; Vesna Sossi ; Doris J. Doudet

Source :

Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging [ 1536-1632 ]

RBID : pubmed:16897319

English descriptors

KwdEn :
- Animals, Autoradiography (methods), Behavior, Animal (physiology), Brain (diagnostic imaging), Brain (drug effects), Carbon Radioisotopes, Dopamine (physiology), Dose-Response Relationship, Drug, Male, Models, Animal, Motor Activity, Oxidopamine (adverse effects), Parkinson Disease (diagnostic imaging), Pilot Projects, Positron-Emission Tomography (methods), Radiography, Rats, Rats, Sprague-Dawley, Tetrabenazine (analogs & derivatives), Tetrabenazine (pharmacokinetics), Tissue Distribution.
MESH :
- chemical , adverse effects : Oxidopamine.
- chemical , analogs & derivatives : Tetrabenazine.
- chemical , pharmacokinetics : Tetrabenazine.
- chemical , physiology : Dopamine.
- chemical : Carbon Radioisotopes.
- diagnostic imaging : Brain, Parkinson Disease.
- drug effects : Brain.
- methods : Autoradiography, Positron-Emission Tomography.
- physiology : Behavior, Animal.
- Animals, Dose-Response Relationship, Drug, Male, Models, Animal, Motor Activity, Pilot Projects, Radiography, Rats, Rats, Sprague-Dawley, Tissue Distribution.

Abstract

In the 6-hydroxydopamine (6-OHDA) rat model of Parkinson's disease (PD), it is important to determine lesion severity. This evaluation can be performed in vivo, through evaluation of dopamine (DA)-dependent motor function or with small animal positron emission tomography (microPET), or at postmortem, by examining markers for DA neurons.

DOI: 10.1007/s11307-006-0051-6
PubMed: 16897319

Affiliations:

Canada

Le document en format XML

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<front><div type="abstract" xml:lang="en">In the 6-hydroxydopamine (6-OHDA) rat model of Parkinson's disease (PD), it is important to determine lesion severity. This evaluation can be performed in vivo, through evaluation of dopamine (DA)-dependent motor function or with small animal positron emission tomography (microPET), or at postmortem, by examining markers for DA neurons.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

Evaluation of the integrity of the dopamine system in a rodent model of Parkinson's disease: small animal positron emission tomography compared to behavioral assessment and autoradiography.

Evaluation of the integrity of the dopamine system in a rodent model of Parkinson's disease: small animal positron emission tomography compared to behavioral assessment and autoradiography.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
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